• Applying genetic engineering tools in zebrafish to study the neuromodulatory role of the choroid plexus 

      Stenersen, Jakob Mørkved (Master thesis, 2022)
      Choroid plexus er et organ som produserer mesteparten av cerebrospinalvæsken (CSV) i kroppen. Denne væsken omslutter hjernen og demper mekaniske slag samtidig som den bidrar til naturlig sirkulering av næring og avfallstoffer. ...
    • Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo 

      Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay (Peer reviewed; Journal article, 2022)
      Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ...
    • Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain 

      Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas; Ringers, Christa; Acuna Hinrichsen, Francisca Daniela; Hui, Subhra; Olstad, Emilie Willoch; Chong, Yan Ling; Lim, Charlton Kang An; Gupta, Astha; Ng, Chee Peng; Nilges, Benedikt S.; Kashikar, Nachiket; Wachten, Dagmar; Liebl, David; Kikuchi, Kazu; Kizil, Caghan; Yaksi, Emre; Roy, Sudipto; Jurisch-Yaksi, Nathalie (Peer reviewed; Journal article, 2021)
      Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not ...
    • Epilepsy as a Network Disorder From Zebrafish to Humans 

      Myren-Svelstad, Sverre (Doctoral theses at NTNU;2022:217, Doctoral thesis, 2022)
    • Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis 

      Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy; Chau, Khac Thanh Phong; Cosacak, Mehmet Ilyas; Diaz Verdugo, Carmen; Palumbo, Fabrizio; Ringers, Christa; Jurisch-Yaksi, Nathalie; Kizil, Caghan; Yaksi, Emre (Peer reviewed; Journal article, 2020)
      The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ...
    • Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis 

      Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Chau, Khac Thanh Phong; Diaz Verdugo, Carmen; Palumbo, Fabrizio; Ringers, Christa; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Serneels, Bram (Peer reviewed; Journal article, 2020)
      The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ...
    • Glia-neuron interactions underlie state transitions to generalized seizures 

      Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Van Hoeymissen, Evelien; Deneubourg, Celine; Vanderhaeghe, Silke; Vancraeynest, Julie; Pelgrims, Robbrecht; Casacak, Mehmet Ilyas; Muto, Akira; Kawakami, Koichi; Jurisch-Yaksi, Nathalie; Yaksi, Emre (Journal article; Peer reviewed, 2019)
      Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ...
    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...
    • Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon 

      Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie (Peer reviewed; Journal article, 2022)
      Motile cilia are hair-like structures that move and propel fluid, playing important roles in the physiology of organs. Here, we present a protocol to visualize and measure ciliary beating and cerebrospinal fluid (CSF) flow ...
    • Motile cilia and their coordination in the nervous system 

      Ringers, Christa (Doctoral theses at NTNU;2021:296, Doctoral thesis, 2021)
    • Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations 

      Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen; Hoffmann, Maximilian; Lal, Pradeep; Kawakami, Koichi; Pekkan, Kerem; Yaksi, Emre; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2017)
      Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical ...
    • Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium 

      Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang; Mick, David; Möglich, Andreas; Jurisch-Yaksi, Nathalie; Schmidt, Florian; Wachten, Dagmar (Peer reviewed; Journal article, 2020)
      Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. ...
    • Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia 

      Ringers, Christa Nelleke; Bialonski, Stephan; Ege, Mert; Solovev, Anton; Hansen, Jan; Jeong, Inyoung; Friedrich, Benjamin; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2023)
    • Origin and role of the cerebrospinal fluid bidirectional flow in the central canal 

      Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; Van Niel, Guillaume; Gallaire, Francois; Wyart, Claire (Peer reviewed; Journal article, 2020)
      Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord ...
    • Past, present and future of zebrafish in epilepsy research 

      Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2021)
      Animal models contribute greatly to our understanding of brain development and function as well as its dysfunction in neurological diseases. Epilepsy research is a very good example of how animal models can provide us with ...
    • The Role of Cilia on Zebrafish Olfaction & Behaviour 

      Ege, Mert (Master thesis, 2020)
      The cilium is a ubiquitous organelle found across species on a wide range of cell types. It is a highly varied structure able to fulfill a plethora of functions; from motile cilia serving in cell motility and establishing ...
    • The role of motile cilia in the development and physiology of the nervous system 

      Jurisch-Yaksi, Nathalie; Ringers, Christa; Olstad, Emile Willoch (Journal article; Peer reviewed, 2019)
      Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary motility results in severe ...
    • The sensory role of motile cilia 

      Reiten, Ingrid (Master thesis, 2016)
      The structure of all cilia is remarkably well conserved from single-celled organisms to mammals, and they have well-established roles as motile and sensory organelles in various species. The propulsive motility of beating ...